TG and thyroid gland disorder: One possible mechanism is that cyanide is transformed into thiocyanate in the body during cigarette smoking, and thiocyanate can concomitantly lead to reduced iodine adsorption and increased iodide efflux, which further enhances the promoting effect of sympathetic stimulation or increases autoimmune thyroid function, which consequently regulates and increases the synthesis of thyroid hormones[33, 38].