IGF2 and colorectal cancer: Knockdown of IGF-II in two inducible colorectal cancer cell lines decreased cellular adhesion to ECM proteins and downregulated several genes involved in cell-cell and cell-matrix contact [64], further emphasizing the role of IGF-II in ECM regulation; the effect of exogenous IGF-II addition to fibroblasts on adhesion molecules was not explored in this study, but could play a role in facilitating the establishment of anchoring proteins for ECM deposition and accumulation.