Fig 1C shows the 20 GPCRs that have >2-fold increased expression (with median expression >1 TPM) in the largest number of tumor types. Fig 1D shows the same, but for GPCRs frequently reduced >2-fold in expression but that are still detected at >1 TPM in those tumors. Among the GPCRs with frequently increased expression are receptors likely expressed in the tumor cells themselves (e.g., GPRC5A [11,12]) and expressed in the tumor microenvironment, such as in fibroblasts (e.g., F2R [13]) and immune cells (e.g., FPR3, CCR1, CCR5). This evidence concerns the gene CCR1 and neoplasm.