Eczema craquelé (asteatotic dermatitis) appears initially (Fig. 1B); then, purpuric eruptions appear in the dry cracking skin and finally turn into tender and painful pustules rapidly within several days when proper treatment is not given.[10] Xerosis is a common cutaneous adverse effect of EGFR inhibitors and appears relatively late, about 1 to 2 months after the start of EGFR inhibitor.[11] Since there is a close association between skin xerosis and PDE, proper skin care with emollient and skin barrier repair should be crucial parts of the treatment for PDE. This evidence concerns the gene ALDH7A1 and Dry skin.