EGFR and Dry skin: Eczema craquelé (asteatotic dermatitis) appears initially (Fig. 1B); then, purpuric eruptions appear in the dry cracking skin and finally turn into tender and painful pustules rapidly within several days when proper treatment is not given.[10] Xerosis is a common cutaneous adverse effect of EGFR inhibitors and appears relatively late, about 1 to 2 months after the start of EGFR inhibitor.[11] Since there is a close association between skin xerosis and PDE, proper skin care with emollient and skin barrier repair should be crucial parts of the treatment for PDE.