Besides, miR-21 has many target genes, but mainly in SPRY1 (sprout homologue 1), PTEN (phosphatase and tensin homologue) and other genes in cardiovascular diseases.[18] In acute myocardial ischemia, miR-21 can inhibit PTEN gene expression and promote matrix MMP-2 expression. The gene discussed is SPRY1; the disease is cardiovascular disorder.