During inflammation, several proinflammatory cytokines (IL-6, TNF-α, IL-1) are secreted in the systemic circulation to initiate the so-called “acute phase response.” Cytokines can independently or synergistically stimulate the hypothalamus and pituitary gland and induce vasopressin release, which causes hyponatremia. Here, TNF is linked to Hyponatremia.