APOM and ischemic stroke: The loss of BBB integrity in Apom-/- mice appeared to be to a lesser extent than in acute pathology (e.g., traumatic brain injury or ischemic stroke), as the BBB permeability towards 10 kDa dextran did not increase in Apom-/- mice (Habgood et al., 2007; Özen et al., 2018).