Specifically, CKD‐504 increased acetylation of several chaperones and E3 ligases as well as tau itself, resulting in recruitment of the novel tau targeting E3 ligases such as UBE2O and RNF14 to tau, which lead to the rescue of synaptic pathology and memory impairment in ADLPAPT mice. The gene discussed is RNF14; the disease is memory impairment.