Several recent studies have reported that reducing endogenous tau attenuates the manifestations of Aβ toxicity, including deficits in axonal transport, seizures, cognitive impairment, and decreased survival, indicating that tau acts as an effector molecule to mediate Aβ toxicity (Roberson et al., 2007; Vossel et al., 2010). This evidence concerns the gene MAPT and Cognitive impairment.