TGFB1 and cancer: Furthermore, 11 KEGG pathways were also enriched, such as hsa05200:Pathways in cancer (CDKN1B, SMAD4), hsa04350:TGF-β signaling pathway (SMAD4) and hsa04110:Cell cycle (CDKN1B, SMAD4) (Table 2; Figure 4).