At the same time, considering the importance of rs6822844 G/T polymorphism in pathogenesis of RA, it is necessary and urgent to perform a comprehensive meta-analysis of all case–control studies that included both each genotype and eligible factors such as rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) status and levels. This evidence concerns the gene PRTN3 and rheumatoid arthritis.