Comparable genome-wide expression profiles between Sox2+ SHH-MB cells and NEPs as well as between Sox2− SHH-MB cells and GCPs suggest that a similar process occurs between tumor regeneration from Sox2+ to Sox2− cells in radiation-treated SHH-MBs and the regeneration of GCPs from NEPs in radiation-treated developing cerebellum.21,29,30. This evidence concerns the gene SOX2 and neoplasm.