Consistent with distinct therapeutic outcomes observed at P35, surviving MB-like lesions all developed into SHH-MBs in radiation-treated Ptch1+/−p53∆E5-6 cerebella, whereas almost no evidence of tumors or proliferating cells was observed in radiation-treated Ptch1+/−p53WT cerebella at P46 (Figure 3A; Supplementary Figure S4A–D). This evidence concerns the gene PTCH1 and Mobius syndrome.