PVT1 and Mobius syndrome: PVT1 fusion genes are highly recurrent, restricted to group 3 MB, arise through a chromothripsis-like process, and were the first recurrent translocation reported in MB.28 The PVT1 locus is thought to be genomically fragile, as the majority of MYC-amplified group 3 MBs harbor PVT1 fusions.