Sibler et al. showed that reintroduction of miR-124 reduced tumor growth in vivo, suggesting therapeutic potential in a subset of MBs overexpressing CDK6.105 MCM2, as a component of the multiprotein MCM2-7 complex, is crucial for DNA replication, transcription, and RNA splicing and is a frequently described oncogene.113 miR-31 targeted and downregulated MCM2 in MB cell lines and reduced tumor growth in vivo,95 and miR-192 was found to be upregulated in metastatic MB compared with nonmetastatic MB,96 inhibiting cellular proliferation and tumor dissemination by targeting integrins. This evidence concerns the gene MCM2 and Mobius syndrome.