miR-199b, a good prognostic marker, was inversely related to metastases in patients.85 In vitro, miR-199b regulated Notch signaling by targeting HES1, which in turn inhibited miR-199b expression.85,86 miR-199b overexpression in cell lines also decreased the CSC population as judged by reduced expression of CD15 (a direct miR-199B target) and CD133 and inhibited tumor growth in vivo. Here, HES1 is linked to neoplasm.