PVT1 and cancer: Of note, a recent study showed that PVT1 lncRNA expression was not required to inhibit MYC transcription; instead, the PVT1 promoter competed with MYC for enhancer binding at the PVT1 locus, preventing MYC promoter firing and suppressing transcriptional elongation of the MYC oncogene and reduced cancer cell growth.57 This might indicate a lncRNA-independent tumor suppressive role for the PVT1 promoter in MB and suggest that regulatory sequences in lncRNA genes may contribute to tumorigenesis.