MCM2 and neoplasm: Sibler et al. showed that reintroduction of miR-124 reduced tumor growth in vivo, suggesting therapeutic potential in a subset of MBs overexpressing CDK6.105 MCM2, as a component of the multiprotein MCM2-7 complex, is crucial for DNA replication, transcription, and RNA splicing and is a frequently described oncogene.113 miR-31 targeted and downregulated MCM2 in MB cell lines and reduced tumor growth in vivo,95 and miR-192 was found to be upregulated in metastatic MB compared with nonmetastatic MB,96 inhibiting cellular proliferation and tumor dissemination by targeting integrins.