A recent transcriptomic study of the SHH-MB CSC miRNome (compared to background neural stem cells) revealed dysregulation of several KEGG pathways including pathways in cancer, the PI3K-AKT pathway, and the protein processing in endoplasmic reticulum pathway.75 In line with these molecular data, most existing studies in MB focusing on eradicating CSCs have focused on specific signaling pathways active in CSCs such as Notch (γ-secretase inhibitors), PI3K/AKT, and STAT3 (celecoxib), with strong preclinical data in mice. This evidence concerns the gene AKT1 and cancer.