Another pro-proliferative miRNA, miR-10b, was found to be upregulated in ERRB2 (HER2)-overexpressing MBs and in SHH MB and group 3 MB cell lines.65,80 miR-10b expression was found to be positively correlated with that of the anti-apoptotic gene BCL2, possibly in a positive feedback loop as knockdown of one downregulated the expression of the other.80 The authors suggested that miR-10b is important for upregulation/maintenance of BCL2 expression, thereby promoting proliferation and inhibiting apoptosis. Here, BCL2 is linked to Mobius syndrome.