Therefore, to explore mechanisms associated with CA- and GA-induced modulation of breast carcinogenesis, we assessed the ligand interaction and binding mode of these compounds with ERα using molecular docking, analyzed associated protein networks and gene interactions using GeneMANIA database, and investigated their effects on hormone receptor positive breast cancer cells (MCF-7), morphological alteration and proliferation by MTT (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay. This evidence concerns the gene ESR1 and breast carcinoma.