TP53 and neoplasm: Furthermore, sub-apoptotic concentrations of cytotoxic compounds can induce growth arrest with senescence features, in which, P53 and P21WAF-1/CIP-1 are essential players; apoptosis plays an important role in myriad physiologic procedures in cell development; therefore, failure in apoptosis facilitates tumor formation and development (Jia et al., 2014; Seresht et al., 2019).