To determine whether the antitumor immune response triggered by the combination of PDT and magnetic hyperthermia sensitizes tumors to checkpoint blockade therapy, we investigated the antitumor activity and antimetastatic effect of CM@M‐MON@Ce6+Laser+ACMF combined with anti‐CTLA‐4 (α‐CTLA‐4) on an orthotropic 4T1 BALB/c mouse tumor model (Figure4a). The gene discussed is CTLA4; the disease is neoplasm.