VWF and Hyperglycemia: In addition, lipid accumulation is attributed to the occurrences of IR and hyperglycemia and causes inflammatory responses by activating the NF‐κB transmission pathway (Cavelti‐Weder et al., 2012), subsequently elevating thrombosis and the expression of several factors that mediate vascular endothelial cell damage such as endothelin‐1 (ET‐1), tissue factor (TF), and von Willebrand factor (vWF; Frankel et al., 2008; Holy & Tanner, 2010; Paneni, Beckman, Creager, & Cosentino, 2013).