However, for the CYP2E1, as shown in Figure 5b, compared with the group A, both expression content and activity were significantly improved in group B (p < .05), which reduced in intervention groups (C, D, E, F) compared with the group B. Genetic polymorphism of enzymes involved in alcohol metabolism plays a relevant role in etiopathogenesis of alcohol disease and alcohol liver cirrhosis (Caro & Cederbaum, 2007; Cichoz, Partycka, Nesina, Celiński, & Saomka, 2006). Here, CYP2E1 is linked to alcoholic liver cirrhosis.