As both LBP and Zn are potent antioxidants and could potentially help to protect the alcohol liver injury, we aimed to explore whether LBP‐ZnSO4 has a synergistic effect in alleviating the detrimental alterations induced by ethanol in rats, such as the imbalance between oxidation and antioxidants, liver injury, and abnormal hemorheology. This evidence concerns the gene LBP and alcohol dependence.