These data showed the tumor suppressor activity of PRUNE2. In conclusion, silencing ADAR1 in LNCaP PCa cell line, which increased PRUNE2 expression as opposed to decreased PCA3 levels, reduced tumor cell proliferation in vitro and in vivo, further demonstrating a functional role for the PRUNE2/PCA3 regulatory axis in PCa [13]. Here, PCA3 is linked to posterior cortical atrophy.