For instance, recent studies have demonstrated that a PCA3 score of 35 provides an optimal balance between sensitivity and specificity in diagnosing PCa with greater diagnostic accuracy than free/total PSA (cut-off 25%) [36, 38]; on the other hand, a PCA3 score threshold lower than 25 could be predictive of pathological indolent PCa [42]. The gene discussed is KLK3; the disease is posterior cortical atrophy.