PCA3 knockdown decreased miR-218-5p expression levels in vitro and in vivo (Figure 2) and miR-218-5p suppressive effects over PCa biological functions are related to high mobility group box 1 (HMGB1) protein repression, suggesting that the PCA3-miR-218-5p-HMGB1 axis could be important for PCa progression [18]. Here, HMGB1 is linked to posterior cortical atrophy.