The triple-negative breast cancer model MDA-MB-468 was selected for this study for the following reasons: (1) MDA-MB-468 cells synthesize low levels of HA (Figure 1A); (2) MDA-MB-468 cells express CD44 [38], making them potential recipients of HA synthesized by stromal cells; and (3) MDA-MB-468 tumors do not grow well in vivo as a xenograft and potentiation by stromal HA could be easily measured. Here, CD44 is linked to triple-negative breast carcinoma.