CD274 and neoplasm: To evaluate the potential prognostic value of immune checkpoint molecules participating in tumor immune escape, a total of ten immunomodulators were analyzed, including two co-stimulatory molecules (CD27 and ICOS) and eight co-inhibitory molecules (PD-1, TIM-3, LAG3, PD-L1, CTLA4, PD-L2, TIGIT and IDO1) (Figure 6).