A principal component-adjusted GWAS study, comprising over 275 000 autosomal variants among 692 adult glioma cases and 3992 controls, identified two SNPs within intron 12 (rs6010620) and intron 17 (rs4809324) of RTEL1 that were significantly associated with glioma and astrocytoma predisposition16. This evidence concerns the gene RTEL1 and central nervous system cancer.