Although the direct function of DSCC1 in tumorigenesis has not been fully elucidated, the present results suggested that DSCC1 is the most important component of the CTF18-1-8 module for functional CTF18-RFC, and is important for the growth and metastasis of colon cancer, thereby making it a potential therapeutic target for colon cancer treatment. Here, DSCC1 is linked to colonic neoplasm.