BRAF and melanoma: Compared with chemotherapy, BRAFi monotherapy demonstrates efficacy in response rate, PFS, and OS for patients with previously untreated stage IV or unresectable stage III melanoma.11,12 Furthermore, the combination of BRAFi and MEKi has better efficacy than monotherapy.13-15 For patients with BRAF mutations, selection between first-line checkpoint immunotherapy and BRAFi can be difficult given the lack of comparative phase III clinical trials.