The IMMs are a group of monoclonal antibodies that block co-inhibitory molecules such as CTLA-4 (expressed on activated CD4+ and CD8+ effector T-cells and regulatory T-cells), PD-1 (also expressed on activated effector T-cells) and its ligand PD-L1 (which is expressed on dendritic cells, activated T-cells, and tumor cells)37. This evidence concerns the gene CD4 and neoplasm.