Therefore, in the current study, we generated a Lin28B-overexpresison cell line, a paclitaxel-resistant HCC cell line and a xenograft tumor model to explore whether Lin28B contributes to chemoresistance in HCC, and explore the underlying mechanism by which curcumin reverses paclitaxel resistance in HCC cells. The gene discussed is LIN28B; the disease is hepatocellular carcinoma.