The ISS divides MM into three phases, ISS I (serum β2-microglobulin levels <= 3.5 mg / L and serum albumin >= 35 g / L), ISS II (excluding the ISS I and ISS III) and ISS III (serum β2-microglobulin levels >= 5.5 mg / L) 4. This evidence concerns the gene HLA-G and Miyoshi myopathy.