In each of the monoclonal immunoglobulin group (except free light chain [FLC] group) of MM, the expression of CHML is obviously different among each ISS stage (Fig. 1B, Kruskal-Wallis test, FLC: P = 0.066, IgA: P = 0.0011, IgG: P = 0.026). This evidence concerns the gene CD79A and Miyoshi myopathy.