MMPs as a family of zinc-dependent proteolytic enzymes (7) include MMP-1, MMP-3, and MMP-9, have the ability to degrade collagen and other ECM proteins, and play a crucial role in different pathophysiology conditions, such as invasion, vascular remodeling, angiogenesis, and tumor metastasis (8, 9). Here, MMP3 is linked to neoplasm.