WNK2 and injury: Our previous study showed that alcohol elevates serum ALT and AST levels, and causes lipid disorders (increased TG, TCH, and LDL-C levels and decreased HDL-C level), while curcumin can reverse these alterations in alcohol-induced liver injury in mice by inhibition of oxidative stress via mitogen-activated protein kinase/nuclear factor E2-related factor 2 pathway (23).