RAF1 and Flavivirus Infections: Because the NS5 is a highly conserved protein among Flavivirus, and its important role during the viral replication and evasion of the host immune system, has led to the proposal of the NS5 as a target for the development of antivirals against Flavivirus infections (El Sahili and Lescar, 2017[23]; Shi and Gao, 2017[72]).