IGF1 and type 1 diabetes mellitus: Indeed, downregulation of f insulin-like growth factor 1 (IGF1) and glucose-6-phosphatase (G6Pase) genes, and also upregulation of the regenerating islet-derived protein 3 gamma gene (Reg3g) have been associated with type 1 diabetes mellitus (Chellappan et al., 2018[27]).