Diabetes mellitus is a polygenic disease involving upregulation and/or downregulation of a genes complex network (ADAMTS9, CDC123/CAMKID, JAZF1, NOTCH2, THADA, TSPAN8/LGRS, PPARG, ABCC8 and KCNJ11, PPARG, HMGA1, HNF4A, IRS1, HNF1A, AKT2, TCF7L2, IGF2BP2, MAPK8IP1, IRS2, NEUROD1, HNF1B, UBC, GCK, FGFR3, others) responsible for the occurrence, progression and complications of the disease (Gupta and Vadde, 2019[73]; Peravali et al., 2019[140]). Here, PPARG is linked to diabetes mellitus.