It consists of four exons and encodes a 340‐amino‐acid protein with two predicted transmembrane (TM) domains in the C‐terminal and one proline‐rich domain in the N‐terminal.41 PRRT2 is involved in a group of paroxysmal disorders, such as epilepsy, paroxysmal kinesigenic dyskinesia(PKD) and migraine 42, 43, but the PRRT2 function and pathogenic mechanisms remain largely obscure. Here, PRRT2 is linked to epilepsy.