It consists of four exons and encodes a 340‐amino‐acid protein with two predicted transmembrane (TM) domains in the C‐terminal and one proline‐rich domain in the N‐terminal.41 PRRT2 is involved in a group of paroxysmal disorders, such as epilepsy, paroxysmal kinesigenic dyskinesia(PKD) and migraine 42, 43, but the PRRT2 function and pathogenic mechanisms remain largely obscure. Here, PRRT2 is linked to migraine disorder.