Neutrophil is a type of myeloid cells recruited first at frontline for host immune defence, but literatures have described this effort being affected by different factors such as tumour growth factor-β (TGF-β), interleukin 1, 6, 10, arginase and chemokine (C–X–C motif) ligand 15 (CXCL 15), which in turn, polarise TAN to contribute for immunosuppressive tumour microenvironment.36,37 The mechanism is poorly understood and discovering this mechanism will be of great importance, however, it is beyond the scope of this clinical finding. This evidence concerns the gene TGFB1 and neoplasm.