Recently, Zhao et al. reported that Meg3 activated apoptosis in myocardial cells in hypoxic atmosphere mediated by FoxO1 pathway [78] Zha et al. reported that Meg3 sponged miR-181a/Egr-1/TLR4 signaling axis and activated inflammatory responses in diabetic nephropathy [33]. The gene discussed is TLR4; the disease is diabetic kidney disease.