Although MYSM1 is functionally essential for deubiquitination of uH2A, the level of uH2A is regulated by multifarious deubiquitinases and ubiquitin ligases [26, 43, 45], implying that the decrease of uH2A in PCa may result from a complex process of ubiquitination and deubiquitination. The gene discussed is MYSM1; the disease is posterior cortical atrophy.