We identified a cluster of lncRNAs (GBAP1, MCM3AP-AS1, SLC16A1-AS1, C3P1, DIO3OS, and HNF4A-AS1) as potential ceRNAs that regulate HCC carcinogenesis and progression, defining them as specific biomarkers to diagnose HCC and predict the prognosis and metastasis of patients with HCC. This evidence concerns the gene HNF4A and hepatocellular carcinoma.