Among them, BAX, BIRC5, ITGA2, and MYB were identified as significantly correlated with the survival of patients with HCC, which was in line with the results of previous studies [28, 44–46], while PRKAA2, PTGIS, PDE7B, CYP8B1, CHEK1, CAMK4, ASPA, and ACSM2A were identified to predict the prognosis of patients with HCC for the first time. This evidence concerns the gene PRKAA2 and hepatocellular carcinoma.