In contrast, another three lncRNAs (C3P1, DIO3OS, and HNF4A-AS1) (Figure 4D–4F, 4J–4L), eight mRNAs (ABAT, ACSM2A, ASPA, CAMK4, CYP8B1, ESR1, IGF1, and PDE7B) (Supplementary Figure 5Ca–5Ch, 6Ca–6Ch) and one miRNA (hsa-let-7c-5p) (Supplementary Figures 5D, 6D) showed low expression in cancer tissues and correlated with longer OS, implying that these transcripts might be protective factors in HCC. This evidence concerns the gene ESR1 and hepatocellular carcinoma.