ESR1 and cancer: In contrast, another three lncRNAs (C3P1, DIO3OS, and HNF4A-AS1) (Figure 4D–4F, 4J–4L), eight mRNAs (ABAT, ACSM2A, ASPA, CAMK4, CYP8B1, ESR1, IGF1, and PDE7B) (Supplementary Figure 5Ca–5Ch, 6Ca–6Ch) and one miRNA (hsa-let-7c-5p) (Supplementary Figures 5D, 6D) showed low expression in cancer tissues and correlated with longer OS, implying that these transcripts might be protective factors in HCC.