Another pathway by which an altered cytokines balance and inflammation can induce anemia is through bone marrow depression (dyserythropoiesis) and erythrophagocytosis following low IL-10 and IL-12 or excess of T helper cell type 1 (th1), cytokines follicular helper T cells (TFH), TNF- α and nitric acid (NO) [42]. The gene discussed is TNF; the disease is anemia (phenotype).