In this work, we discovered the low content of m6A modification in bladder tumorigenesis and bladder TICs (shown in Figs. 1 and 2), and identified the role of m6A modification and Mettl14 through various functional assays, including sphere formation, transwell invasion assay, gradient tumor initiation assay, tumor propagation assay and Ki67 staining (shown in Figs. 4 and 5). Here, MKI67 is linked to neoplasm.