It has previously been shown that CD34+ fibroblasts are preferentially expressed in healthy tissue and benign tissue alterations,26, 28, 44, 45 unlike SMA+ fibroblasts, that were associated with a higher probability of malignant venous infiltration in the study by Nishishita et al. 31 and showed higher presence in primary tumors and macrometastases.30, 46 Here, we were able to demonstrate that the supposed grade of invasiveness,45 characterized by the TNM tumor stage and its lymphonodal spread, is related to the level of SMA+ CAFs in stage I‐III NSCLC. This evidence concerns the gene CD34 and neoplasm.