Additionally, in a neuroendocrine application, cells obtained from the urine of patients with multiple endocrine neoplasia type 1 syndrome (MEN1) were used to generate iPSCs with non-integrated episomal plasmids carrying Oct4, Sox2, Klf4, and miR-302-367 without using c-Myc [45] [46],. This evidence concerns the gene KLF4 and multiple endocrine neoplasia type 1.