This might be a result of different patterns of cortical atrophy, as those who develop AD without ApoE-ε4 display cortical atrophy predominantly in fronto-parietal cortex, which is accompanied by executive function deficits, whereas AD patients with ApoE-ε4 display cortical atrophy predominantly in the mediotemporal cortex, which is accompanied by memory deficits (Wolk et al. 2010). Here, APOE is linked to Alzheimer disease.