Breast cancer cells with hypermethylated E-cadherin gene promoter adopt spindle like morphology and often have markers of epithelial mesenchymal transition (EMT), a global epigenetic/differentiation program through which cancer cells gain the ability to invade and metastasize (Graff et al. 1995; Lombaerts et al. 2006). Here, CDH1 is linked to breast carcinoma.