LDLR and Cognitive impairment: However, controversy still exists as to whether the associations between these 3 adjacent genes and cognition are independent of APOE allele or are driven by LD with APOE. The biochemical interaction between APOC1 and APOE may be associated with cognitive impairment, since the binding of triglyceride lipoproteins to the very low density lipoprotein receptor, mediated by APOE allele, could be interfered by over-expressed ApoC1 [26].