We identified genome-wide significant associations of 3 SNPs (rs4420638, rs56131196, rs157582) in the TOMM40-APOC1 region with hippocampal atrophy rate and 3 additional suggestive association loci (in TOMM40 gene and near MIR302F gene). The gene discussed is MIR302F; the disease is hippocampal atrophy.