After adjusting for age, gender, years of education, intracranial volume (ICV), MRI and the first three multidimensional scaling (MDS) components, 3 SNPs on chromosome 19, including rs4420638 in the APOC1 gene (minor allele frequencies (MAF) = 0.1510, P = 9.32 × 10-9), rs56131196 in the APOC1 gene (MAF = 0.1508, P = 1.10 × 10-8) and rs157582 in the TOMM40 gene (MAF = 0.2937, P = 2.78 × 10-8), exhibited genome-wide significant associations with hippocampal atrophy rate (Figure 1A and Table 2). This evidence concerns the gene APOC1 and hippocampal atrophy.