We believe that one of the main strengths of our study relies in the study design: the four AD CSF biomarkers (Aβ42, Aβ40, t-Tau, and p-Tau) were measured simultaneously, from the same aliquot, using both the Lumipulse and INNOTEST assays; the same batch of reagents for each marker/assay was used and a standard CSF pre-analytical procedure was followed throughout the study. This evidence concerns the gene MAPT and Alzheimer disease.