Previous study has found that AKAP6 protein is highly expressed in the brain (10), and we also used the GEPIA database (http://gepia.pku.cn/) to predict the expression of AKAP6 mRNA, the result showed that the mRNA level of AKAP6 gene was significantly up-regulated in glioma (p < 0.05, Additional file 2: Figure S2). The gene discussed is AKAP6; the disease is central nervous system cancer.