While there is a little variability in HLA-G coding region and protein, both promoter and 3’ untranslated (3’UTR) regions bear polymorphisms which affect the levels of HLA-G expression (Castelli et al., 2011; Martelli-Palomino et al., 2013), and some have been associated with different pathologies such as cancer and autoimmune diseases (Hachiya et al., 2016; Rolfsen et al., 2014). The gene discussed is HLA-G; the disease is cancer.