Over the last decade, NF-κB became a major target in drug discovery due to its key role in cancer development, cell proliferation and survival, inflammation, and immune responses (Ahn et al., 2007; Sethi et al., 2008; Sethi et al., 2009; Li and Sethi, 2010; Orlikova et al., 2012; Sethi et al., 2012; Shin et al., 2014; Li et al., 2015b; Monisha et al.,2016; Monisha et al., 2017; Ningegowda et al., 2017; Pires et al., 2018; Mohan et al., 2018; Puar et al., 2018). The gene discussed is NFKB1; the disease is cancer.