EGFR and neoplasm: EGFR signaling triggers intracellular signaling pathways such as the STAT signaling pathway, phosphoinositide 3-kinase (PI3K)/Akt pathway, and the Ras/Raf/MEK/ERK1/2 pathway, which enhances tumor cell proliferation, angiogenesis, invasion, metastasis, and apoptosis resistance (Seshacharyulu et al., 2012; Wang et al., 2013; Barr Kumarakulasinghe et al., 2015; Oronsky et al., 2018; Yang and Tam, 2018).