In addition, expression of receptors like Oestrogen Receptor (ER), Progesterone Receptor (PR) and Her2/neu are well established prognostic and predictive factors for breast cancer which imparts credence to the significance of various clinic-pathological parameters in prognosis and prediction in response to several available therapeutic options in breast cancer (Singh et al., 2016). This evidence concerns the gene ESR1 and breast carcinoma.