FGFR2 and breast carcinoma: Various meta-analysis studies have been conducted and reported that SNP FGFR2 rs2981582 TT is linked to an increased risk of BC, but until now the exact mechanism of carcinogenesis linking SNP FGFR2 rs2981582 TT to BC, especially early breast cancer onset has not been found (Zhang et al., 2010; Peng et al., 2011).