CAV1 and neoplasm: Integrin-mediated adhesion can modulate lipid rafts trafficking such that upon cell detachment, the phosphorylation of Cav-1 and its location change from focal adhesions to caveolae induce lipid rafts internalization and clearance, resulting in inhibition of PI-3 kinase, Erk, and Rac, thus suppressing tumor growth (del Pozo et al., 2005).