The co-culture of human breast cancer cells (MCF7) and immortalized fibroblasts (hTERT-BJ1) or normal human mammary fibroblasts leads to autophagic/lysosomal degradation and down regulation of Cav-1 in fibroblasts, resulting in cancer associated fibroblast (CAFs) phenotype(Martinez-Outschoorn et al., 2010a). The gene discussed is CAV1; the disease is breast cancer.