Mucopolysaccharidosis type I (MPS I, OMIM#252800), an autosomal alpha‐L‐iduronidase (IDUA, EC 3.2.1.76) deficiency, resulting from IDUA (NG_008103.1) mutations affects the enzyme activity of alpha‐L‐iduronidase. The gene discussed is IDUA; the disease is Scheie syndrome.