Our study provides further evidence that circ‐TCF4.85 rescued the miR‐486‐5p‐induced inhibition of its target gene ABCF2. Hence, it is reasonable to suggest that silencing of circ‐TCF4.85 inhibits ABCF2 to retard HCC progression by upregulating miR‐486‐5p. This evidence concerns the gene TCF4 and hepatocellular carcinoma.