Next, we plotted a receiver operating characteristic (ROC) curve for the differentiating value of circ‐TCF4.85 in HCC patients from normal controls as depicted in Fig. 1F. The area under the curve was calculated to be 0.891 (95% confidence interval = 0.820–0.962; P < 0.001). This evidence concerns the gene TCF4 and hepatocellular carcinoma.