In conclusion, the current study provides evidence that circ‐TCF4.85 knockdown upregulates miR‐486‐5p to hinder the cell proliferation, migration, and invasion and induce apoptosis by downregulating the expression of ABCF2 in HCC, highlighting inhibition of circ‐TCF4.85 as a potential target to prevent the initiation or progression of HCC (Fig. 8). This evidence concerns the gene ABCF2 and hepatocellular carcinoma.