A potential mechanism of circ‐TCF4.85 was implicated in the occurrence of hepatocellular carcinoma (HCC) via regulation of ABCF2. In HCC cells, circ‐TCF4.85 bound to microRNA‐486‐5p (miR‐486‐5p) that targeted and negatively regulated ABCF2. Overexpression of circ‐TCF4.85 reduced the expression of miR‐486‐5p, and then increased that of ABCF2, thus promoting proliferation, migration, and invasion while suppressing the apoptosis of HCC cells. The gene discussed is TCF4; the disease is hepatocellular carcinoma.