In addition, miR‐486‐5p is poorly expressed in HCC, and functions to inhibit HCC cell growth, invasion, migration, and facilitate apoptosis so as to repress tumor growth via regulation of PIK3R1 and phosphatidylinositol 3‐kinase‐AKT activation (Huang et al., 2015; Zhang et al., 2014). This evidence concerns the gene AKT1 and hepatocellular carcinoma.