Our study provides further evidence that circ‐TCF4.85 rescued the miR‐486‐5p‐induced inhibition of its target gene ABCF2. Hence, it is reasonable to suggest that silencing of circ‐TCF4.85 inhibits ABCF2 to retard HCC progression by upregulating miR‐486‐5p. Here, ABCF2 is linked to hepatocellular carcinoma.